Colorectal Oncogenomics Group

Discovering the causes of colorectal cancer, reducing its incidence, and improving patient outcomes.
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Overview

Our research includes the identification and investigation of clinically and biologically relevant subtypes of colorectal cancer (CRC), including both familial and non-familial CRC, that can be identified through genetic, epigenetic, somatic and histopathological characterisation of CRC tumours and their pre-malignant lesions (polyps).

Key research areas
  • Identifying novel genetic risk factors for CRC.
  • Improving our understanding of major CRC-related diseases, such as Lynch Syndrome and Serrated Polyposis Syndrome
  • Identifying biomarkers of risk and poor prognosis in CRC.

News

Recent presentations

  • Tumour profiling in MMR-deficient subtypes of Endometrial Cancer, Australia and New Zealand Gynaecological Oncology Group (ANZGOG), Melbourne, Australia, 2020.
  • Tumor Microbiome in Subtypes of Mismatch Repair Deficient Colorectal Cancer, AACR The Microbiome, Viruses and Cancer, Melbourne, Australia, 2020.
  • Tumour immunity signatures to expand current diagnostic approaches in mismatch repair deficient cancers in the context of Lynch Syndrome through InSituPlex technology and Tissue Phenomics integration, Society for Immunotherapy in Cancer (SITC), National Harbor, USA, 2019.

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Recent publications

  • Genotoxic colibactin mutational signature in colorectal cancer is associated with clinicopathological features, specific genomic alterations and better survival., medRxiv, 2023.
  • A tumor focused approach to resolving the etiology of DNA mismatch repair deficient tumors classified as suspected Lynch syndrome., medRxiv, 2023.
  • Evaluating Multiple Next-Generation Sequencing-Derived Tumor Features to Accurately Predict DNA Mismatch Repair Status., J Mol Diagn, 2023.

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Recent activities

  • March, 2019: Attended and presented at the International Society for Gastrointestinal hereditary tumours (InSiGHT) meeting in Auckland, New Zealand
  • 26 - 30 November, 2018: Attended and presented at the Australian Bioinformatics and Computational Biology Society Conference in Melbourne, Australia
  • 3 - 4 September, 2018: Attended and presented at Familial Aspects of Cancer: Research and Practice in Kingscliff, NSW, Australia.
  • December 2017 - February 2018: James Chan undertakes student project investigating copy number variation in Familial Colorectal Cancer Type X.

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